INFLUENCE OF LYMPH FLOW RATE ON CONCENTRATIONS OF PROTEINS AND DEXTRAN IN DOG LEG LYMPH
- WL Joyner
- RD Carter
- EM Renkin
Control measurements of lymph:plasma concentration ratios (R) for total protein, albumin, globulin and Dextran-110 over a more than 60-fold range of spontaneous lymph flows (L) in legs of 72 dogs show an inverse relation of R and L which is in qualitative agreement with the prediction of Drinker's theory of lymph formation and some of its more recent elaborations. At low to moderate lymph flow rates, the relation conforms to the simplified relation R = PS/(PS + L) where PS is a permeability·surface area product PS for plasma globulins (mainly gamma, effective radius 55 Å) is about half that for serum albumin (35.5 Å) and PS for Dextran-110 (71 Å) is about one-sixth. The decrease of PS with increasing molecular size characterizes the sieving properties of the bloodlymph barrier. There is considerable variation of PS values among preparations, even under supposedly normal conditions. Legs with high lymph flows tend to have high permeabilities and show diminished sieving.
How to Cite:
Joyner, W. & Carter, R. & Renkin, E., (1973) “INFLUENCE OF LYMPH FLOW RATE ON CONCENTRATIONS OF PROTEINS AND DEXTRAN IN DOG LEG LYMPH”, Lymphology 6(4), 181-186.