LYMPHATIC TRANSPORT OF ENZYMES AFTER EXPERIMENTAL MYOCARDIAL INFARCTION
- G Szabo (University of Arizona)
- Z Magyar
- A Reffy
The concentrations of LDH, MDH, GOT, creatine kinase, acid and alkaline phosphatase were examined in dogs in the cardiac lymph, arterial and coronary sinus blood serum prior to the occlusion of a descending branch of the left coronary artery and at 1, 2, 4, 6, and 24 hours thereafter. Lymphatic concentrations of LDH, MDH, GOT and CPK increased within the 1st to 2nd hour; serum levels rose later and remained below the lymphatic concentrations. 6 hours after the onset of the infarction there was a significant arterial-coronary sinus difference in the concentration of some enzymes. In serum a shift was observed in the LDH isoenzyme pattern in the direction of the preponderance of H subunits.
The changes in serum concentrations of the mitochondrial and lysosomal enzymes alkaline and acid phosphatase in the infarct animals did not differ from those observed in sham operated controls and their concentration in cardiac lymph remained below serum concentration.
The increase of the concentration of the cytoplasmic enzymes in cardiac lymph is the earliest sign of myocardial damage. The rise of serum levels of enzymes of cardiac origin in animals with cannulated cardiac lymph vessel and the presence of an arterio-venous concentration difference are positive evidences for direct venous transport of the enzyme proteins from the myocardium.
How to Cite:
Szabo, G. & Magyar, Z. & Reffy, A., (1974) “LYMPHATIC TRANSPORT OF ENZYMES AFTER EXPERIMENTAL MYOCARDIAL INFARCTION”, Lymphology 7(1), p.37-44.