SPLEEN REGENERATION IN MICE AFTER GAMMA IRRADIATION AND ADMINISTRATION OF THYMOSIN
- J Vavrova
- P Petyrek
The effect of thymosin (thymic humeral factor isolated from calf thymus) on regeneration of the spleen in mice after whole-body gamma irradiation was studied. Thymosin, in varied dosages (0.1-2.0 mg/day) applied subcutaneously before and after radiation exposure, stimulated splenic regeneration as indicated by increased splenic weight, number of endogenous splenic colonies and 59Fe and 125IUdR incorporation into the spleen. A control extract of brain tissue (cerebrosin) isolated in the same way as thymosin was applied to mice to verify specificity of thymosin. After cerebrosin application, a mild increase also was observed. Whereas a near maximal effect of thymosin was reached at a dosage of 0.1 mg, a comparable response with cerebrosin required a dosage of 1.0 mg. These data suggest that administration of thymosin has both a specific and nonspecific effect on splenic regeneration and proliferation of hematopoietic stem cells.
How to Cite:
Vavrova, J. & Petyrek, P., (1979) “SPLEEN REGENERATION IN MICE AFTER GAMMA IRRADIATION AND ADMINISTRATION OF THYMOSIN”, Lymphology 12(4), 275-279.