Articles

CHYLOTHORAX AS RARE MANIFESTATION OF PLEURAL INVOLVEMENT IN WALDENSTRÖM MACROGLOBULINEMIA: MECHANISMS AND MANAGEMENT

Authors
  • G Leoncini
  • CC Campisi
  • G Fraternali Orcioni
  • F Patrone
  • F Ferrando
  • Carol Campisi

Abstract

Here we report the clinical, pathological, and immunological features of a rare case of Waldenström macroglobulinemia (WM) with pleural infiltrations. An atypical chylothorax, successfully treated by videothoracoscopy, represented the main clinical feature of this case of low-grade lymphoplasmacytic lymphoma. Pleuropulmonary manifestations are rare (from 0 to 5% of cases) in WM, with chylothorax observed in just seven patients worldwide. In addition to describing this uncommon clinical presentation, we investigate hypothetical pathogenetic mechanisms causing chylothorax and through an up-to-date review of available literature furnish helpful suggestions for diagnosis and management of chylothorax in WM patients.

Keywords: Waldenström macroglobulinemia, chylothorax, thoracic duct, pleural effusion, talc pleurodesis, videothoracoscopy

How to Cite:

Leoncini, G., Campisi, C., Fraternali Orcioni, G., Patrone, F., Ferrando, F. & Campisi, C., (2016) “CHYLOTHORAX AS RARE MANIFESTATION OF PLEURAL INVOLVEMENT IN WALDENSTRÖM MACROGLOBULINEMIA: MECHANISMS AND MANAGEMENT”, Lymphology 49(4), 210-217.

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Published on
21 Mar 2016
Peer Reviewed