Articles

RECIRCULATION OF LYMPHOCYTES: ITS ROLE IN IMPLEMENTING IMMUNE RESPONSES IN THE SKIN

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Abstract

A number of recent investigations have suggested that the subset of lymphocytes which migrate into non-lymphoid tissue to appear in peripheral lymph may be partly different from the major recirculating pool migrating through lymphoid tissues. We report results on the migration from the blood of thoracic duct lymphocytes labelled with ⁵¹Cr and three subsets-accredited recirculators, activated lymphocytes and "long-lived" lymphocytes. The localization of these populations was studied in normal skin, in a contact sensitivity lesion and in a site of non-immune inflammation. All four populations localized in the contact sensitivity lesion in increased numbers compared to normal skin but "long-lived" lymphocytes appeared to discriminate between cell-mediated immunity and non-immune inflammation; activated lymphocytes migrated most efficiently into the non-immune inflammatory site (Table 4).

How to Cite:

Rannie, G. & Ford, W., (1978) “RECIRCULATION OF LYMPHOCYTES: ITS ROLE IN IMPLEMENTING IMMUNE RESPONSES IN THE SKIN”, Lymphology 11(4), 193-201.