Articles

EFFECTS OF CORTICOSTEROID AND RADIATION ON LYMPHOID TISSUE IN MICE. COMPARISONS AND MUTUAL INTERACTIONS.

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Abstract

The phases of involution and regeneration in the lymphoid tissues of mice were compared between total body irradiation with a single dose of 500 R and injection of a single dose of 8 mg prednisolone. These dosages induced a comparable degree of acute involution of the thymic cortex, and were the minimum dosages which, in the acute phase, produced cytolysis of all cortisal small lymphocytes, with a largely preserved medulla.

After steroid treatment the lymphocytolysis in the lymph nodes, spleen and the Peyers patches was most marked in the germinal centres whereas the so-called thymic dependent areas were mainly preserved. After irradiation compared to steroid-treatment the cytolysis was definitely more pronounced in all parts of these lymphoid tissues, including the white pulp of the spleen, the whole follicles and the subcapsular parts of the lymph node cortex and the follicles and partially the interfollicular areas of the Peyers patches.

From the time of the first regeneration of the thymic cortex after irradiation, steroid sensitive cells could be found in all lymphoid tissues, indicating that the pool of these cells regenerates rapidly after irradiation.

How to Cite:

Lundin, P. & Jarplid, B., (1973) “EFFECTS OF CORTICOSTEROID AND RADIATION ON LYMPHOID TISSUE IN MICE. COMPARISONS AND MUTUAL INTERACTIONS.”, Lymphology 6(3), 158-166.