ULTRASTRUCTURAL EVIDENCE FOR THE LYMPH NODE-VENOUS TRANSPORT OF CARBON PARTICLES
- RF Dunn
Abstract
The primary response of the lymph node sinus endothelial cells to increased intrasinusoidal pressure appears to be an opening of overlap junctions between adjacent endothelial cells. When colloidal carbon particles are injected via an afferent lymphatic, the tracer is found within the patent overlap junctions, the sinus endothelial cells, and the interstitial tissue that separates lymphatic sinuses and nearby capillaries. Carbon particles generally are confined to capillary lumens when injected via the communicating vein that joins the lymph node and the adjacent internal jugular vein. The long-term removal of carbon particles appears to be via an endocytic process, primarily by sinus endothelial cells and sinus macrophages with secondary uptake by fixed parenchymal macrophages. Minimal uptake of the tracer by capillary endothelial cells precludes the capillaries as a major site of removal of tracers from lymph node sinuses.
How to Cite:
Dunn, R., (1973) “ULTRASTRUCTURAL EVIDENCE FOR THE LYMPH NODE-VENOUS TRANSPORT OF CARBON PARTICLES”, Lymphology 6(2), 79-90.
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