OXYGEN TENSION OF NEARLY PURE PULMONARY LYMPH IN UNANESTHETIZED SHEEP
- NC Staub
- EL Schultz
Abstract
Bergofsky (1, 2) measured the oxygen tension (Po2) of thoracic duct (TD) lymph and equated it with average tissue Po2 • Other workers have made similar comparisons for kid ney (3) and intestinal tract (4).
Said and Banerjee (5) used this concept to calculate the fraction of lung lymph in right lymphatic duct (RLD) lymph in anesthetized dogs. They found the average Po2 = 75 torr; the same as the average arterial Po2 and considerably higher than TD Po2 . Using standard mixing equations, assuming pure lung lymph Po2 equaled alveolar gas Po2 and non-respira tory lymph equaled TD Po2 they computed that 53% of RLD lymph came from the lung.
Recently, Meyer and Ottaviani (6) made similar Po2 measurements both for RLD and TD normally and in acute edema. They confirmed the apparently high Po2 in RLD lymph and calculated that most of RLD lymph came from the lung. Assuming body lymph Po2 equaled mixed venous Po2, they concluded that 15% of TD lymph originated in the lung. Since TD flow greatly exceeded RLD flow, the net result was that about two thirds of pul monary lymph entered the thoracic duct both in normal and edematous conditions.
Unfortunately, both RLD and TD lymph have traversed lymph nodes and Mayerson (7) has shown that small molecules (molcular weight< 1,000) equilibrate completely during lymph node transit.
Because of the importance of lymph gas tension in the lung and elsewhere, wo have reassess ed the oxygen tension of pulmonary lymph obtained from four unanesthetized sheep with chronic lymph catheters. We devised an oxygen-impermeable, external catheter system and measured steady state Po2 repeatedly over several hours. Our finding is that the average Po2 of nearly pure lung lymph is very similar to that of mixed venous blood. It is not related to the tissue Po2 at its source.
How to Cite:
Staub, N. & Schultz, E., (1974) “OXYGEN TENSION OF NEARLY PURE PULMONARY LYMPH IN UNANESTHETIZED SHEEP”, Lymphology 7(2), 96-100.
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