Articles

THE EFFECTS OF INTRAVENOUS INFUSION OF SOLUTIONS WITH DIFFERENT COLLOID OSMOTIC PRESSURES ON RAT MESENTERIC LYMPH PRESSURE

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Abstract

The effects of intravenous infusion of solutions of varied colloid osmotic pressure on mesenteric lymph pressure were measured by a glass micropipette. The lymph pressure was 4.0 ± 1.6 cm H₂0 between the second and third valve of rat mesenteric lymphatic vessels with diameter of 101 ± 25μm (mean ± SD). Intravenous infusion of 1 ml/100g body weight (B.W.) of isotonic saline, 5% glucose solution, and 20% glucose solution increased the lymph pressure by 1.6 ± 0.5 cm H₂0, 1.5 ± 0.3 cm H₂0 and 2.0 ± 1.0 cm H₂0, respectively. Infusion of 2 ml/100g B.W. of the same solutions increased the lymph pressure by 3.3 ± 1.3 cm H₂0, 3.3 ± 1.6 cm H₂0 and 3.7 ± 0.8 cm H₂0, respectively . Infusion of hydroxyethyl starch solution, with colloid osmotic pressure of 25 mmHg, minimally altered the lymph pressure. One ml/100g B.W. infusion of low molecular weight dextran solution, with colloid osmotic pressure of 162 mmHg, decreased the lymph pressure by 1.3 ± 0.9 cm H₂0, and 2 ml/100g B.W . infusion of this solution decreased the lymph pressure by 2.0 ± 1.0 cm H₂0. The different effects on lymph pressure derive from the differences in colloid osmotic pressure of these solutions in conformity with the Starling hypothesis.

How to Cite:

Shinozaki, M., Morio, M., Kikuchi, H., Yamanoue, T., Fujii, K. & Kodama, K., (1986) “THE EFFECTS OF INTRAVENOUS INFUSION OF SOLUTIONS WITH DIFFERENT COLLOID OSMOTIC PRESSURES ON RAT MESENTERIC LYMPH PRESSURE”, Lymphology 19(3), 109-116.