Articles

THE TOPOGRAPHY OF MERCURIAL LYMPHADENOPATHY IN BROWN NORWAY RATS

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Abstract

Injection of mercuric chloride caused a progressive systemic lymphadenopathy and splenomegaly in Brown Norway (BN) but not in Lewis rats, as reported by others. We studied the number, duration and route of HgCl₂ treatments and the topography of the resultant lymphadenopathy, as well as its age and strain dependency. Five injections of HgCl₂ increased three-fold the weight of the lymph nodes which became considerably heavier than the spleen. Weanling rats were less susceptible than adults. A regional lymphadenopathy could not be produced. However, a synergistic interaction was observed when the systemic effects of HgCl₂ were added to the regional lymphadenopathy produced by injections of metal powders, such that the lymph node mass approached 2% of body weight.

How to Cite:

Levine, S. & Saltzman, A., (1988) “THE TOPOGRAPHY OF MERCURIAL LYMPHADENOPATHY IN BROWN NORWAY RATS”, Lymphology 21(3), 161-168.