LEVELS OF EICOSANOIDS (6-OXO-PGF1α AND 8-EPI-PGF2α ) IN HUMAN AND PORCINE LYMPHATICS AND LYMPH
- A Oguogho
- J Kaliman
- H Sinzinger
Abstract
Prostaglandin (PG)I2 is the primary eicosanoid synthesized by human lymphatics and 8-epi-PGF2α, an isoprostane formed during free radical catalyzed peroxidation,is the most potent stimulator of lymphatic contraction tested thus far. We now examine the respective concentrations in the lymphatic wall of both human and porcine lymphatics and lymph fluid using specific immunoassays. Although both compounds are detectable in the lymphatic wall and lymph fluid, PGI2- (via its main metabolite 6-oxo-PGF1α) is greater in the lymphatic wall whereas 8-epi-PGF2α dominates in lymph fluid. Because inflammation is associated with oxidative injury, which in turn stimulates release of isoprostane, eicosanoid derivatives may modulate lymphatic tone during acute tissue reaction.
How to Cite:
Oguogho, A., Kaliman, J. & Sinzinger, H., (1998) “LEVELS OF EICOSANOIDS (6-OXO-PGF1α AND 8-EPI-PGF2α ) IN HUMAN AND PORCINE LYMPHATICS AND LYMPH”, Lymphology 31(4), 186-189.
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