MESENTERIC LYMPH NODE TRANSPLANTATION IN SYNGENEIC RATS: CHANGES IN CELLULARITY AND ARCHITECTURE
- NF Liu
- J Maldik
- W Olszewski
Abstract
The cellular architectural and functional changes of transplanted mesenteric lymph nodes in rats were studied. After lymph nodes were transplanted with interruption of both the afferent and efferent lymphatics, the nodal cellular content gradually became depleted. One month after operation, the recirculating lymphocyte count in the transplanted node was only 3.5% of that in control nodes, whereas the number of mononuclear cells per mg tissue of transplanted node was only 28% of normal. In the transplanted nodal paracortex, the cells of high endothelial venules (HEV) became less prominent and gradually flattened altogether. In the transplanted nodal cortex, germinal centers and follicles also sharply decreased and later disappeared. Three months after transplantation, the normal compartmentalization of the transplanted nodes were no longer distinguishable. Regeneration of afferent lymphatics was not detected in transplanted nodes and the lack of circulating antigen and stimulated lymphocytes was probably responsible for the histological and functional involution of grafted mesenteric lymph nodes.
How to Cite:
Liu, N., Maldik, J. & Olszewski, W., (1992) “MESENTERIC LYMPH NODE TRANSPLANTATION IN SYNGENEIC RATS: CHANGES IN CELLULARITY AND ARCHITECTURE”, Lymphology 25(3), 139-144.
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