Articles

PROSTAGLANDIN I2 SYNTHASE IN THE LYMPHATIC ENDOTHELIUM OF RAT LIVER AS REVEALED BY PREEMBEDDING IMMUNOELECTRON MICROSCOPY

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Abstract

Localization of prostaglandin I₂ synthase-like immunoreactivity (PGI₂SI) in the lymphatic endothelium of rat liver was investigated by means of preembedding immunoelectron microscopy. Vesicular and multivesicular bodies with PGI₂SI were closely apposed to Golgi complexes of the endothelial cells. Membrane-bounded PGI₂SI structures including vesicular and dense bodies were also present beneath the endothelial plasmalemma on both luminal and abluminal sides. Other organelles within the endothelial cells did not exhibit PGI₂SI. These findings are consistent with previous biochemical and physiological studies suggesting prostaglandin I₂ is produced in the Golgi apparatus and released into luminal and abluminal spaces through membrane-bounded structures containing PGI₂SI.

How to Cite:

Ito, Y., Magari, S. & Sakanaka, M., (1989) “PROSTAGLANDIN I2 SYNTHASE IN THE LYMPHATIC ENDOTHELIUM OF RAT LIVER AS REVEALED BY PREEMBEDDING IMMUNOELECTRON MICROSCOPY”, Lymphology 22(1), 51-55.