Articles

PRECURSORS OF 8-LYMPHOCYTES WITH SURFACE IgM AND THEIR POSSIBLE MIGRATION FROM BONE MARROW TO PERIPHERAL LYMPHATIC TISSUES

Authors: L Jaroskova ( ) , I Trebichavsky ( ) , F Kovaru ( ) , L Prokesova ( )

Abstract

The lymphocytes with surface immunoglobulins (sIg) represent precursors of B-lymphocytes and were studied in ontogeny of pigs by autoradiography using iodinated monospecific anti-µ , anti-g or anti-α antibodies. The earliest detection of sIgM⁺ small lymphocytes was at 44 days of gestation in liver, followed at 51 days in spleen and at 60 days in bone marrow, the thymocytcs being sIg-negative. The first circulating small lymphocytes were detected at 38-40 days and are most probably thymus-derived.

In adult pigs as well as after immunization of germ-free piglets IgM remains to represent the surface Ig on bone marrow lymphocytes while in peripheral lymphatic tissues there is appearance of lymphocytes labelled with anti-g or anti-α. The percentage of sIgM⁺ lymphocytes in bone marrow is extremely small and also the density of sIgM per cell is low.

Keywords:

How to Cite: Jaroskova, L. , Trebichavsky, I. , Kovaru, F. & Prokesova, L. (1978) “PRECURSORS OF 8-LYMPHOCYTES WITH SURFACE IgM AND THEIR POSSIBLE MIGRATION FROM BONE MARROW TO PERIPHERAL LYMPHATIC TISSUES”, Lymphology. 11(2).