PRECURSORS OF 8-LYMPHOCYTES WITH SURFACE IgM AND THEIR POSSIBLE MIGRATION FROM BONE MARROW TO PERIPHERAL LYMPHATIC TISSUES
- L Jaroskova
- I Trebichavsky
- F Kovaru
- L Prokesova
The lymphocytes with surface immunoglobulins (sIg) represent precursors of B-lymphocytes and were studied in ontogeny of pigs by autoradiography using iodinated monospecific anti-µ , anti-g or anti-α antibodies. The earliest detection of sIgM+ small lymphocytes was at 44 days of gestation in liver, followed at 51 days in spleen and at 60 days in bone marrow, the thymocytcs being sIg-negative. The first circulating small lymphocytes were detected at 38-40 days and are most probably thymus-derived.
In adult pigs as well as after immunization of germ-free piglets IgM remains to represent the surface Ig on bone marrow lymphocytes while in peripheral lymphatic tissues there is appearance of lymphocytes labelled with anti-g or anti-α. The percentage of sIgM+ lymphocytes in bone marrow is extremely small and also the density of sIgM per cell is low.
How to Cite:
Jaroskova, L. & Trebichavsky, I. & Kovaru, F. & Prokesova, L., (1978) “PRECURSORS OF 8-LYMPHOCYTES WITH SURFACE IgM AND THEIR POSSIBLE MIGRATION FROM BONE MARROW TO PERIPHERAL LYMPHATIC TISSUES”, Lymphology 11(2), 81-83.