CHRONIC LYMPHOCYTIC LEUKAEMIA AND THE MIXED LYMPHOCYTE REACTION
- CR Pentycross
The lymphocytes from patients with chronic lymphocytic leukaemia (CLL) have been studied in the mixed lymphocyte reaction (MLR) using both the two-way (both populations viable) and one-way (only one viable population) systems. The ABO antigens were matched but the pairs were selected for at least two antigenic differences of the HL-A system. The lymphocytes of the patients were as capable as normal cells of invoking a response in allogeneic normal lymphocytes. Conversely, barely any response was produced when the lymphocytes of the patients were exposed to non-viable normal allogeneic cells. The failure of the leukaemic lymphocytes to respond adequately in the MLR is correlated with a very poor response to phytohaemagglutinin and may be contrasted with the definite positive responses obtained with specific antigens.
How to Cite:
Pentycross, C., (1974) “CHRONIC LYMPHOCYTIC LEUKAEMIA AND THE MIXED LYMPHOCYTE REACTION”, Lymphology 7(1), 7-12.