@article{lymph 4260, author = {A Malik, H van der Zee, B Lee}, title = {PULMONARY TRANSVASCULAR FLUID DYNAMICS IN SHEEP DURING HEMORRHAGE}, volume = {12}, year = {1979}, url = {http://journals.librarypublishing.arizona.edu/lymph/article/id/4260/}, issue = {3}, abstract = {<p>The effects of hemorrhage on pulmonary hemodynamics and lung transvascular fluid dynamics were studied in sheep. We found that 2 hr of hemorrhage caused a fall in lung lymph flow (p < 0.05 ) and no sigificant change in lymph protein concentration. The fall in lymph flow was not due to decreased vascular surface area since the regional distribution of pulmonary perfusion was not altered during hemorrhage; however the decrease in lymph flow was associated with decrease (p < 0.05 ) in the calculated pulmonary microvascular pressure. The extravascular lung water lung content per g blood less dry lung was increased (p < 0.05 ) in the hemorrhaged sheep from the control values. Pulmonary edema was not due to increased lung vascular endothelial permeabiltly since the net tran vascular protein flux was not increased. The finding that pulmonary edema occurred despite the consistent decreases in lymph flow suggests that edema may be due to hemorrhage-induced lymphatic "failure" or that edema fluid is sequestered in spaces (e.g., endothelial cells) where it cannot be drained by the lymphatics.</p>}, month = {9}, pages = {149-157}, issn = {2522-7963}, publisher={International Society of Lymphology and the University of Arizona Libraries}, journal = {Lymphology} }