Authors: M Kondo ( ) , K Hosakawa ( ) , M Masuda ( )
Fibrinolytic activity in the biopsicd gastrointestinal mucosa was investigated in patients with proteinlosing gastroenteropathy, and the increased activity was observed in patients associated with erosive gastritis, Menetrier's disease, atrophic gastritis, or Crohn's disease. However, patients with intestinal lymphangiectasia showed normal mucosal fibrinolysis. Antifibrinolytic therapy with tranexan1ic acid revealed significant therapeutic effect in the group with increased mucosal fibrinolysis. It is concluded that tranexamic acid appeared to be successful in blocking the vicious circle of "membrane disorder", "increased tissue fibrinolysis", "increased vascular permeability", and "hypoproteinemia" in protein-losing gastroenteropathy.
How to Cite: Kondo, M. , Hosakawa, K. & Masuda, M. (1979) “NEW APPROACH TO PROTEIN-LOSING GASTROENTEROPATHY”, Lymphology. 12(1).