TY - JOUR AB - <p>kg/min PGE<sub>1</sub> for 15 min increased the lymph flow by between 13% and 81% for up to 45 min after the infusion, as measured at the plasma-lymph barrier of the hind limbs of rabbits. The lymph flow normalized after 105 min. The ED<sub>50</sub> for PGE<sub>1</sub> 15 min after infusion was 19 ng/kg/min. PGE<sub>1</sub> did not influence the permeation of macromolecules (PVP, proteins) from plasma to lymph. With a dose of 50 ng/kg/min severe side-effects appeared. The dose of 25 ng/kg/min did not produce any haemodynamic effects.</p><p>Intravenous injections of 0.25 to 0.8 mg/kg of aescin or 2.5 to 20 mg/kg of indomethacin reduced the increased lymph flow, obtained by injecting 25 ng/kg/ min of PGE<sub>1</sub> by 45% to 92% and 13% to 68% respectively for up to 45 min after infusion of PGE<sub>1</sub>. The dose of 20 mg/kg i.v. of indomethacin as compared with 10 mg/kg did not show an increased efficacy but resulted in severe side-effects. The ED<sub>50</sub> of aescin was 0.29 mg/kg i.v. and that of indomethacin 3.4 mg/kg i.v. 45 min after PGE<sub>1</sub> infusion.</p><p>According to these results both aescin and indomethacin had an antagonistic effect on the increased permeability of the plasma-lymph barrier of the hind limbs of rabbits induced by PGE<sub>1</sub>.</p> AU - M Rothkopf -lschebeck, G Vogel DA - 1980/9// IS - 1 VL - 13 PB - International Society of Lymphology and the University of Arizona Libraries PY - 1980 TI - THE EFFECT OF PROSTAGLANDIN E<sub>1</sub> (PGE<sub>1</sub>) ON THE PLASMA-LYMPH BARRIER OF THE HIND LIMB OF RABBITS AND ITS ANTAGONIZATION BY AESCIN AND LNDOMETHACIN T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/4211/ ER -