TY - JOUR AB - <p>Blood-borne cells with the characteristics described for the natural killer (NK) lymphocytes were recovered from the liver sinusoids in rat. They had cytotoxic activity against K 562 cells in a 18 h <sup>51</sup>Cr release assay. target binding rate and large granular lymphocytes percentage higher than the inflowing portal blood cells. The cytotoxic effector population was non-adherent and peroxidase negative, enriched in cells with Fc- and C36-receptors. Deprivation of liver of portal or mesenteric blood supply significantly decreased the liver NK activity not affecting the level of cytotoxicity in the portal blood. Splenectomy produced only a moderate decrease of activity. These findings may indicate that liver sinusoids is the site of accumulation of blood-born NK cells or of maturation of the NK-precursors. One possible mechanism by which natural cytotoxicity cotrols tumor growth and spread might be the killing of circulating tumor cells arrested in the liver by the blood-born NK-cells.</p> AU - B Lukomska, T Ruffa, L Olszewski, A Engeset DA - 1983/9// IS - 4 VL - 16 PB - International Society of Lymphology and the University of Arizona Libraries PY - 1983 TI - NATURAL KILLER LYMPHOCYTES IN RAT LIVER SINUSOIDAL BLOOD T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/4097/ ER -