Articles

ARACHIDONIC ACID METABOLITES OF HUMAN LYMPHATICS

Authors: H Sinzinger ( ) , J Kaliman ( ) , E Mannheimer ( )

Abstract

Human lymphatics convert exogenously added ¹⁴C-arachidonic acid into PGE₂, PGF₂alpha and the main metabolite 6-keto-PGF₁alpha. Thromboxane formation is undetectable either by radiothinlayer-chromatography or by radioimmunology. These data confirm and extend our earlier findings indicating an important PGI₂-synthetic mechanism in human lymphatics. Assuming that lymphatic contractility is regulated at least in part by thromboxane A₂, we propose that this derivative of arachidonic acid derives from extralymphatic sources.

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How to Cite: Sinzinger, H. , Kaliman, J. & Mannheimer, E. (1984) “ARACHIDONIC ACID METABOLITES OF HUMAN LYMPHATICS”, Lymphology. 17(2).