Articles

CELLULAR COMPOSITION OF LYMPH IN EXPERIMENTAL LYMPHEDEMA

Authors
  • H Galkowska
  • WL Olszewski

Abstract

Lymph cell populations were characterized immunologically in dogs with chronic postsurgical lymphedema. There was a 10- to 30-fold increase in lymph total cell count as compared with normal (control) dogs. Morphologically, these were predominantly small lymphocytes with approximately 4-6% monocytes and veiled cells. In contrast, lymph from normal dogs contained 33% granulocytes and 27% monocytes. The Fc-R+ and C3b-R+ mononuclear nonadherent cells were less represented in lymph in chronic stasis than in normals. A high autotransformation rate of lymph cells and marked responsiveness to PHA and Con A were also observed. In chronic lymphedema K-cell and NK-cell cytotoxicity were lower than in normal lymph. Interruption or retardation of the lymphocyte recirculation pathway with lymph stasis may alter regulation of immune responsiveness in lymphedematous tissue.

How to Cite:

Galkowska, H. & Olszewski, W., (1986) “CELLULAR COMPOSITION OF LYMPH IN EXPERIMENTAL LYMPHEDEMA”, Lymphology 19(4), 139-145.

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Published on
10 Jul 1986
Peer Reviewed