@article{lymph 3960, author = {L Athlin, L Domellof, BO Norberg}, title = {THE PHAGOCYTOSIS OF YEAST CELLS BY MONOCYTES: EFFECTS OF COLCHICINE, BETA-LUMICOLCHICINE, AND GAMMA-LUMICOLCHICINE}, volume = {19}, year = {1986}, url = {http://journals.librarypublishing.arizona.edu/lymph/article/id/3960/}, issue = {3}, abstract = {<p>The effect of microtubule antagonist (MA) colchicine and its two non-MA derivatives Beta-lumicolchicine and Gamma-lumicolchicine on the phagocytosis of yeast cells by glass-adherent monocytes were studied with a fluorescence quenching technique which allowed a distinction between the adherence and engulfment phases of phagocytosis. The engulfment of yeast cells was depressed by colchicine (p = 0 .031) but not by the lumicolchicines. The adherence of yeast cells to the monocytes, on the other hand, was depressed by Gamma-lumicolchicine (p = 0.028).</p><p>The colchicine effect suggests that cytoplasmic microtubules play a role in the engulfment process whereas the lumicolchicine effect suggests a role of nucleoside transport over the cell membrane in the adherence process of phagocytosis.</p>}, month = {7}, pages = {130-135}, issn = {2522-7963}, publisher={International Society of Lymphology and the University of Arizona Libraries}, journal = {Lymphology} }