THE PHAGOCYTOSIS OF YEAST CELLS BY MONOCYTES: EFFECTS OF COLCHICINE, BETA-LUMICOLCHICINE, AND GAMMA-LUMICOLCHICINE
- L Athlin
- L Domellof
- BO Norberg
The effect of microtubule antagonist (MA) colchicine and its two non-MA derivatives Beta-lumicolchicine and Gamma-lumicolchicine on the phagocytosis of yeast cells by glass-adherent monocytes were studied with a fluorescence quenching technique which allowed a distinction between the adherence and engulfment phases of phagocytosis. The engulfment of yeast cells was depressed by colchicine (p = 0 .031) but not by the lumicolchicines. The adherence of yeast cells to the monocytes, on the other hand, was depressed by Gamma-lumicolchicine (p = 0.028).
The colchicine effect suggests that cytoplasmic microtubules play a role in the engulfment process whereas the lumicolchicine effect suggests a role of nucleoside transport over the cell membrane in the adherence process of phagocytosis.
How to Cite:
Athlin, L. & Domellof, L. & Norberg, B., (1986) “THE PHAGOCYTOSIS OF YEAST CELLS BY MONOCYTES: EFFECTS OF COLCHICINE, BETA-LUMICOLCHICINE, AND GAMMA-LUMICOLCHICINE”, Lymphology 19(3), p.130-135.