Articles

A NOVEL FLT4 GENE MUTATION AND MR LYMPHANGIOGRAPHY IN A CHINESE FAMILY WITH MILROY DISEASE

Authors: N-F Liu ( ) , Z Yu ( ) , Y Luo ( ) , D Sun ( ) , Z Yan ( )

Abstract

Milroy disease is a congenital onset lymphedema linked to FLT4 gene mutations in the tyrosine kinase domain. So far, a total of 59 different FLT4 variants have been identified. Here, we report a novel FLT4 gene mutation in a Chinese family with Milroy disease and present their clinical symptoms and MR lymphangiographic findings.

Keywords: Milroy disease, FLT4, VEGFR-3, primary lymphedema, novel gene mutation, MR lymphangiogram, phenotype

How to Cite: Liu, N. , Yu, Z. , Luo, Y. , Sun, D. & Yan, Z. (2015) “A NOVEL FLT4 GENE MUTATION AND MR LYMPHANGIOGRAPHY IN A CHINESE FAMILY WITH MILROY DISEASE”, Lymphology. 48(2).