Articles

LIPEDEMA IS ASSOCIATED WITH INCREASED AORTIC STIFFNESS

Authors
  • G Szolnoky
  • A Nemes
  • H Gavaller
  • T Forster
  • L Kemeny

Abstract

Lipedema is a disproportional obesity due to unknown pathomechanism. Its major hallmark is frequent hematoma formation related to increased capillary fragility and reduced venoarterial reflex. Beyond microangiopathy, both venous and lymphatic dysfunction have also been documented. However, arterial circulation in lipedema has not been examined, and therefore we explored aortic elastic properties by echocardiography. Fourteen women with and 14 without lipedema were included in the study. Each subject consented to blood pressure measurement,physical examination, and transthoracic echocardiography. Aortic stiffness index (ß), distensibility, and strain were evaluated from aortic diameter and blood pressure data. Mean systolic (30.0 ± 3.2 vs. 25.5 ± 3.6, P<0.05) and diastolic (27.8 ± 3.3 vs. 22.3 ± 3.1) aortic diameters (in mm) and aortic stiffness index (9.05 ± 7.45 vs. 3.76 ± 1.22, P<0.05) were significantly higher, while aortic strain (0.082 ± 0.04 vs. 0.143 ± 0.038, P<0.05) and distensibility (2.24 ± 1.07 vs. 4.38 ± 1.61, P<0.05) were significantly lower in lipedematous patients compared to controls. Thus, lipedema is characterized with increased aortic stiffness.

Keywords: lipedema, aortic stiffnes, echocardiography, blood pressure

How to Cite:

Szolnoky, G. & Nemes, A. & Gavaller, H. & Forster, T. & Kemeny, L., (2012) “LIPEDEMA IS ASSOCIATED WITH INCREASED AORTIC STIFFNESS”, Lymphology 45(2), 71-79.

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Published on
17 Aug 2012
Peer Reviewed