TY - JOUR AB - <p>Fetal chylothorax is one of a very few syndromes that can be treated in utero with thoracoamniotic shunting or pleurodesis by OK-432 as two major therapeutic modalities. We report on a fetus with Noonan syndrome and a missense mutation c.182A&gt;C (p.Asp61Ala) of PTPN11 who responded poorly to antenatal pleurodesis by OK-432. Based on our previous publication and this case study, we propose that fetal chylothorax of a distinct genetic origin may respond poorly to OK-432 pleurodesis.</p> AU - C-H Chen, T-H Chen, S-J Kuo, C-P Chen, D-J Lee, Y-Y Ke, K-T Yeh, G-C Ma, C-S Liu, J-C Shih, M Chen DA - 2009/8// IS - 3 VL - 42 PB - International Society of Lymphology and the University of Arizona Libraries PY - 2009 TI - GENETIC EVALUATION AND MANAGEMENT OF FETAL CHYLOTHORAX: REVIEW AND INSIGHTS FROM A CASE OF NOONAN SYNDROME T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/3651/ ER -