TY - JOUR AB - <p>FOXC2 mutations cause the lymphatic/ocular disorder Lymphedema-Distichiasis (LD), and Foxc2 haploinsufficient mice mimic this disorder. To determine ifFOXC2 overexpression might also cause lymphatic and/or ocular abnormalities, we performed dynamic lymphatic imaging (Evansblue dye), ocular tissue examination, and metabolic profiles in mice: transgenic forFOXC2 with an adipocyte (aP2) promoter (aP2-FOXC2 Tg), heterozygous for targeted disruption of Foxc2 (Foxc2<sup>+/-</sup>), or compound heterozygous and transgenic (Foxc2<sup>+/-</sup>, Tg) compared to wild-type controls (WT). Foxc2<sup>+/-</sup>; aP2-FOXC2 Tg; and Foxc2<sup>+/-</sup>, Tg, exhibited LD's distinctive hyperplastic lymphatic phenotype characterized by increased number of lymphatic channels and lymph nodes as well as retrograde lymph reflux. Foxc2<sup>+/-</sup>, andFoxc2<sup>+/-</sup>, Tg but not a P2-FOXC2 Tg or WT showed an abnormal ocular phenotype. Previously described alterations in brown/white fat distribution and lean phenotype in aP2-FOXC2 transgenics were confirmed. AP2-FOXC2 Tg immunohistochemistry disclosed aberrant FOXC2 expression in ectopic sites,especially embryonic heart. Lymphatic system links with fat metabolism are discussed.</p> AU - A Noon, RJ Hunter, MH Witte, B Kriederman, MJ Bernas, M Rennels, D Percy, S Enerback, RP Erickson DA - 2006/8// IS - 2 VL - 39 PB - International Society of Lymphology and the University of Arizona Libraries PY - 2006 TI - COMPARATIVE LYMPHATIC, OCULAR, AND METABOLIC PHENOTYPES OF FOXC2 HAPLOINSUFFICIENT AND AP2-FOXC2 TRANSGENIC MICE T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/3582/ ER -