Articles

EFFECT OF PHOSPHODIESTERASE III INHIBITOR (OLPRINONE) ON THORACIC DUCT LYMPH FLOW IN ANESTHETIZED SHEEP WITH EXPERIMENTALLY INDUCED HEART FAILURE BY ENDOTHELIN-1

Authors: M Tomoyasu ( ) , M Onizuka ( ) , M Inagaki ( ) , Y Sato ( ) , T Yamamoto ( ) , S Ishikawa ( ) , T Mitsui ( )

Abstract

We investigated the short-term effects of a phosphodiesterase III Inhibitor (Olprinone) on hemodynamics and thoracic duct lymph flow in anesthetized open-chest sheep with heart failure induced by endothelin-l (cardiogenic shock). Ultrasound transit-time flow probes were attached to the thoracic duct, the ascending aorta and the renal artery. Arterial, pulmonary and central venous pressures were monitored. Endothelin-l was infused intravenously at a dosage that reduced cardiac output to 50% or more of baseline(n=11). The effects of Olprinone were examined (n=5) by intravenous infusion after endothelin-l administration. Other sheep(n=6) were used as controls. Olprinone significantly increased cardiac output that had been decreased by endothelin-l and further increased thoracic duct flow that had been increased by endothelin-l. Increased arterial and pulmonary pressures induced byendothelin-l administration were rapidly decreased by Olprinone. Renal arterial flow and central venous pressure were, however,unchanged by Olprinone. Overall, Olprinone acutely improved experimental cardiogenic shock (heart failure) induced by endothelin-l, and maintained thoracic duct lymph flow at a high level after endothelin-l administration.

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How to Cite: Tomoyasu, M. , Onizuka, M. , Inagaki, M. , Sato, Y. , Yamamoto, T. , Ishikawa, S. & Mitsui, T. (2002) “EFFECT OF PHOSPHODIESTERASE III INHIBITOR (OLPRINONE) ON THORACIC DUCT LYMPH FLOW IN ANESTHETIZED SHEEP WITH EXPERIMENTALLY INDUCED HEART FAILURE BY ENDOTHELIN-1”, Lymphology. 35(4).