@article{lymph 3393, author = {H Sinzinger, J Kaliman, A Oguogho}, title = {EICOSANOID PRODUCTION AND LYMPHATIC RESPONSIVENESS IN HUMAN CIGARETTE SMOKERS COMPARED WITH NON-SMOKERS}, volume = {33}, year = {2000}, url = {http://journals.librarypublishing.arizona.edu/lymph/article/id/3393/}, issue = {1}, abstract = {<p>Leg lymphatic segments were isolated from 10 patients (4 cigarette smokers and 6 nonsmokers) undergoing conventional lymphography. Prostaglandin (PG) levels and PG synthesis in the lymphatics and in a variety of body fluids and the effects of eicosanoids on lymphatic contractility were determined. Leg lymphatics from 4 smokers generated less PGI<sub>2</sub> and contained more 8-epi-PGF<sub>2α</sub> when compared with leg lymphatics in 6 non-smokers. Similarly, levels of 8-epi-PGF<sub>2α</sub> in smokers compared with non-smokers were higher in plasma (28.6 cf 19.7 pg/ml),leg lymph (146.7 cf 65.3 pg/ml), serum (299.0 cf 204.1 pg/ml), and urine (473.4 cf 241.0 pg/mg creatinine). Lymphatics from smokers also showed a higher contractile response, less <sup>14</sup>C-arachidonic acid conversion to PGI<sub>2</sub> and less PGI<sub>2</sub>-formation with various stimuli compared with non-smokers. Together these findings suggest that smoking induces oxidation injury, promotes altered (iso-)eicosanoid production and impacts on the function and dysfunction of peripheral lymphatics under normal circumstances and in a variety of clinical disorders.</p>}, month = {8}, pages = {24-31}, issn = {2522-7963}, publisher={International Society of Lymphology and the University of Arizona Libraries}, journal = {Lymphology} }