Articles

EFFECT OF TUMOR NECROSIS FACTOR-α AND INTERLEUKIN-2 ON SPLEEN LYMPHOCYTE MIGRATION IN MOUSE SKIN

Authors
  • J Sun
  • Z Liu
  • Y Bi
  • Z Guo
  • T Hua
  • Z Ding

Abstract

Tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) are reported to enhance lymphocyte binding to endothelial cells in vitro. We examined these two agents on lymphocyte migration in vivo. Spleen lymphocytes were radiolabeled with tritiated uridine (3H-UR) and then injected IV into mice. Each cytokine (TNF-α or IL-2) or both cytokines were then injected intradermally on the back of mice. The results demonstrated that TNF-α stimulates lymphocyte migration in vivo in dose-dependent fashion. Kinetic analysis demonstrated that migration with TNF-α started at 3h, peaked at 6h, followed by a gradual decline back to baseline at 24h. IL-2, on the other hand, was nearly inactive, and did not augment lymphocyte migration over and above that induced by TNF-α when both cytokines were injected together.

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How to Cite:

Sun, J. & Liu, Z. & Bi, Y. & Guo, Z. & Hua, T. & Ding, Z., (1999) “EFFECT OF TUMOR NECROSIS FACTOR-α AND INTERLEUKIN-2 ON SPLEEN LYMPHOCYTE MIGRATION IN MOUSE SKIN”, Lymphology 32(4), p.166-170.

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Published on
26 Aug 1999
Peer Reviewed