TY - JOUR AB - <p>Prostaglandin (PG)I<sub>2</sub> is the primary eicosanoid synthesized by human lymphatics and 8-epi-PGF<sub>2α</sub>, an isoprostane formed during free radical catalyzed peroxidation,is the most potent stimulator of lymphatic contraction tested thus far. We now examine the respective concentrations in the lymphatic wall of both human and porcine lymphatics and lymph fluid using specific immunoassays. Although both compounds are detectable in the lymphatic wall and lymph fluid, PGI<sub>2-</sub> (via its main metabolite 6-oxo-PGF<sub>1α</sub>) is greater in the lymphatic wall whereas 8-epi-PGF<sub>2α</sub> dominates in lymph fluid. Because inflammation is associated with oxidative injury, which in turn stimulates release of isoprostane, eicosanoid derivatives may modulate lymphatic tone during acute tissue reaction.</p> AU - A Oguogho, J Kaliman, H Sinzinger DA - 1998/8// IS - 4 VL - 31 PB - International Society of Lymphology and the University of Arizona Libraries PY - 1998 TI - LEVELS OF EICOSANOIDS (6-OXO-PGF<sub>1α</sub> AND 8-EPI-PGF<sub>2α</sub> ) IN HUMAN AND PORCINE LYMPHATICS AND LYMPH T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/3360/ ER -