ISOPROSTANE 8-EPI-PROSTAGLANDIN F2α IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS
- H Sinzinger
- A Oguogho
- J Kaliman
Isoprostanes are products of free radical-catalyzed peroxidation and 8-epiprostaglandin (PG) F2α is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF2α stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE1, 8-epi-PGE2) had only limited lymphatic contractile potency. These data suggest a potentially relevant role for 8-epi-PGF2α in facilitating lymph transport especially in conditions of inflammation.
How to Cite:
Sinzinger, H. & Oguogho, A. & Kaliman, J., (1997) “ISOPROSTANE 8-EPI-PROSTAGLANDIN F2α IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS”, Lymphology 30(3), 155-159.