Authors: P Poggi ( ) , C Marchetti ( ) , A Calligaro ( ) , A Casasco ( ) , R Scelsi ( )
Myotonic dystrophy is an hereditary disorder of several organ systems. Skeletal muscle is a principal target organ, but abnormalities also occur in the peripheral microcirculation. Because morphological and functional changes in the dermal blood microcirculation may affect interstitial fluid drainage of the skin, we examined dermal lymphatic morphology in adult patients with myotonic dystrophy. Skin biopsies were taken from the big toe from patients with myotonic dystrophy (age 18-50 years) and subjected to light and electron microscopy; five healthy subjects served as controls. The salient findings in myotonic dystrophy were ultrastructural changes of the lymphatic endothelial cells and the fibrillar elements that surround the lymphatic wall. These abnormal lymphatic findings are interpreted in light of changes in the blood microvasculature and loose connective tissue in this disorder.
How to Cite: Poggi, P. , Marchetti, C. , Calligaro, A. , Casasco, A. & Scelsi, R. (1992) “DERMAL LYMPHATICS IN MYOTONIC DYSTROPHY”, Lymphology. 25(4).