IMMUNE PROTEINS IN PERIPHERAL TISSUE FLUID-LYMPH IN PATIENTS WITH FILARIAL LYMPHEDEMA OF THE LOWER LIMBS
- WL Olszewski
- S Jamal
- B Lukomska
- G Manokaran
- I Grzelak
Abstract
Immune proteins and cytokine concentrations and activity were measured in skin tissue fluid-lymph and blood serum of patients with lower leg filarial lymphedema. High levels of lymph gamma-globulins, alpha-1-acid glycoprotein and IgG lymph/serum ratio were found. Lymph from filarial patients had an elevated lymph stimulatory effect on blood mononuclear cell culture with phytohemagglutinin. There was also a high concentration and activity of IL-1 beta but gamma-interferon was not detected. The deranged pattern of immune proteins and high activity of IL-1 suggest persistence of an ongoing local inflammatory process despite the absence of overt dermatitis. The high tissue-lymph IL-1 concentration and activity may signify a cytokine network promoting keratinocyte and fibroblast proliferation commonly seen on skin histology in patients with filariasis.
How to Cite:
Olszewski, W. & Jamal, S. & Lukomska, B. & Manokaran, G. & Grzelak, I., (1992) “IMMUNE PROTEINS IN PERIPHERAL TISSUE FLUID-LYMPH IN PATIENTS WITH FILARIAL LYMPHEDEMA OF THE LOWER LIMBS”, Lymphology 25(4), 166-171.
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