Articles

A PLAN TO SUPPRESS OR PREVENT THE IMMUNE REJECTION OF ALLOGRAFTED ORGANS

Authors
  • M Jocoby
  • M Brock

Abstract

Progress in the resolution of allograft rejection and associated complications has been hampered by the nonselective nature of current immunosuppressive therapy. In the following protocol, we proposed instead of broadly suppressing immunoreactivity to remove selectively from the bloodstream supplying the transplanted organ only those T lymphocytes and/or antibodies capable of reacting with and destroying the allograft. This goal is to be accomplished by offering them (T cells and/or antibodies) a decoy of antigenically identical tissue. The proposed procedure has the added advantage that it may activate suppressor T cells specific for the allogenic tissue, thereby further promoting acceptance of the graft while providing the host immune system the opportunity to recognize the allograft as autochthonous.

How to Cite:

Jocoby, M. & Brock, M., (1992) “A PLAN TO SUPPRESS OR PREVENT THE IMMUNE REJECTION OF ALLOGRAFTED ORGANS”, Lymphology 25(1), 42-47.

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Published on
09 Sep 1992
Peer Reviewed