Articles

THE EFFECTS OF VASOACTIVE DRUGS ON HALOTHANE INHIBITION OF CONTRACTIONS OF RAT MESENTERIC LYMPHATICS

Authors: T Takeshita ( ) , M Kawahara ( ) , K Fujii ( ) , H Kinoshita ( ) , M Morio ( )

Abstract

The effects of halothane on alpha-adrenergic receptors, beta-adrenergic receptors, and the process of Ca⁺⁺ dependent contractions on rat mesenteric lymphatics were examined. Halothane depressed the contraction rate of mesenteric lymphatics but did not effect the increase in lymphatic contraction rate caused by noradrenaline (an α-agonist). The depressant effect of halothane on the contraction rate was also not antagonized by propranolol (a β-blocker), but was partly reversed by CaCl₂. These findings suggest that the depressant effect of halothane on the lymphatic contraction rate derives not from blocking lymphatic alpha-receptors or stimulating lymphatic beta-receptors but rather by halothane inhibition on the process of Ca⁺⁺ dependent lymphatic contractions.

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How to Cite: Takeshita, T. , Kawahara, M. , Fujii, K. , Kinoshita, H. & Morio, M. (1989) “THE EFFECTS OF VASOACTIVE DRUGS ON HALOTHANE INHIBITION OF CONTRACTIONS OF RAT MESENTERIC LYMPHATICS”, Lymphology. 22(4).