PREPARATION AND EVALUATION OF TC-99M HYDROXY-ETHYL STARCH AS A POTENTIAL RADIOPHARMACEUTICAL FOR LYMPHOSCINTIGRAPHY:
- S Sadek
- A Owunwanne
- HM Abdel-Dayem
- T Yacoub
Tc-99m hydroxyethyl starch (Tc-99m HES) prepared with a labeling efficiency greater than 95% was evaluated in rabbits for visualization of lymphatic channels and lymph nodes, and the findings compared with Tc-99m human serum albumin (Tc-99m HSA), Tc-99m dextran (Tc-99m DXT), and Tc-99m sulfur microcolloid (Tc-99m SMC). Tc-99m HES showed good visualization of lymphatic channels and regional nodes and it had the highest clearance rate from the injection site (p less than 0.01). Tc-99m HES showed greater uptake by the nodes than Tc-99m DXT (p less than 0.001) at 90 minutes post-injection. The concentration of Tc-99m HES in the lymphatic channels was higher than that of Tc-99m SMC at 90 minutes post-injection (p less than 0.001). Preliminary clinical studies of Tc-99m HES yielded high quality lymphoscintigrams of the leg, and the pelvic and para-aortic lymph nodes in less than 10 minutes post-injection. In addition, partially and completed obstructed lymphatics could be differentiated from normal lymphatic pathways. In conclusion, Tc-99m HES is a promising radiopharmaceutical for imaging of lymphatic channels and nodes.
How to Cite:
Sadek, S. & Owunwanne, A. & Abdel-Dayem, H. & Yacoub, T., (1989) “PREPARATION AND EVALUATION OF TC-99M HYDROXY-ETHYL STARCH AS A POTENTIAL RADIOPHARMACEUTICAL FOR LYMPHOSCINTIGRAPHY:”, Lymphology 22(4), p.157-166.