Articles

HISTOLOGIC CHANGES IN DOG LYMPH NODES AFTER ENDOLYMPHATIC APPLICATION OF BLEOMYCIN OIL SUSPENSION

Authors: P Hirnle ( ) , M Geppert ( )

Abstract

Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment). Granulomatous reaction, microabscesses, and small necrotic foci were observed. After a month, fibrosis was detectable in all lymph nodes. The damage to microscopic lymph node structures after Oil-Bleo was moderate. These findings suggest that Oil-Bleo may be useful in local treatment of lymph node metastases.

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How to Cite: Hirnle, P. & Geppert, M. (1989) “HISTOLOGIC CHANGES IN DOG LYMPH NODES AFTER ENDOLYMPHATIC APPLICATION OF BLEOMYCIN OIL SUSPENSION”, Lymphology. 22(2).