TY - JOUR AB - <p>Localization of prostaglandin I<sub>2</sub> synthase-like immunoreactivity (PGI<sub>2</sub>SI) in the lymphatic endothelium of rat liver was investigated by means of preembedding immunoelectron microscopy. Vesicular and multivesicular bodies with PGI<sub>2</sub>SI were closely apposed to Golgi complexes of the endothelial cells. Membrane-bounded PGI<sub>2</sub>SI structures including vesicular and dense bodies were also present beneath the endothelial plasmalemma on both luminal and abluminal sides. Other organelles within the endothelial cells did not exhibit PGI<sub>2</sub>SI. These findings are consistent with previous biochemical and physiological studies suggesting prostaglandin I<sub>2</sub> is produced in the Golgi apparatus and released into luminal and abluminal spaces through membrane-bounded structures containing PGI<sub>2</sub>SI.</p> AU - Y Ito, S Magari, M Sakanaka DA - 1989/11// IS - 1 VL - 22 PB - International Society of Lymphology and the University of Arizona Libraries PY - 1989 TI - PROSTAGLANDIN I2 SYNTHASE IN THE LYMPHATIC ENDOTHELIUM OF RAT LIVER AS REVEALED BY PREEMBEDDING IMMUNOELECTRON MICROSCOPY T2 - Lymphology UR - http://journals.librarypublishing.arizona.edu/lymph/article/id/3075/ ER -