Epstein-Barr virus-associated transformation of primary cutaneous follicle center lymphoma to diffuse large B-cell lymphoma, a case and review of the literature

Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is a rare, indolent neoplasm with a good prognosis. Transformations of PCFCL into more aggressive non-Hodgkin lymphomas, such as diffuse large B-cell lymphoma (DLBCL), are extremely uncommon, with few cases reported in the literature. We present a case report of an 84-year-old man with a history of PCFCL who presented 26 months after initial treatment with an enlarged lymph node in the right neck. Excisional biopsy revealed DLBCL. Further studies showed the presence of Epstein-Barr virus (EBV), and molecular studies were consistent with the two neoplasms being clonally related. Taken together, these findings suggest an EBV-driven transformation of PCFCL to DLBCL in this patient.

Keywords

Primary cutaneous follicle center lymphoma (PCFCL), Epstein-Barr virus (EBV), diffuse large B-cell lymphoma (DLBCL), transformation

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Alver, A. & Haycocks, N. G., (2021) “Epstein-Barr virus-associated transformation of primary cutaneous follicle center lymphoma to diffuse large B-cell lymphoma, a case and review of the literature”, Hematopathology 5(1), p.12-17.

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Authors

Amalie Alver (University of Nevada, Las Vegas School of Medicine)
Neil G. Haycocks (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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