B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and mantle cell lymphoma

Abstract

The expression of cyclin D1 in diffuse large B-cell lymphomas has been reported in the literature several times. However, cases with the t(11;14)(q13;q32) are very uncommon. Herein, we present two cases of diffuse large B-cell lymphoma with the t(11;14)(q13;q32) and cyclin D1 expression, BCL6 rearrangement and BCL2 amplification, but negative for SOX11 expression. Although presence of the t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma, it can also be seen in diffuse large B-cell lymphoma, sometimes as a secondary aberration.

Keywords

Diffuse large B-cell lymphoma, cyclin D1, t(11;14)(q13;q32)

How to Cite

Cantu, D. & Pillai, R. & Homan, S. & Nathwani, B. & Weisenburger, D. D., (2019) “B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and mantle cell lymphoma”, Hematopathology 4(1), p.1-8.

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Authors

David Cantu (City of Hope National Medical Center, Duarte, CA)
Raju Pillai (City of Hope National Medical Center, Duarte, CA)
Suzanne Homan (City of Hope National Medical Center, Duarte, CA)
Bharat Nathwani (City of Hope National Medical Center, Duarte, CA)
Dennis D. Weisenburger (City of Hope National Medical Center, Duarte, CA)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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