The Uncommon Faces of Classic Hodgkin Lymphoma

Abstract

Diagnosis of classic Hodgkin lymphoma (CHL) is quite straightforward with the integrated clinical, morphological, and immunophenotypic studies. Due to the variation in morphology and immunophenotype, CHL diagnosis remains a challenge. Based on their many years of experience in diagnostic practice, the authors summarized eleven uncommon variants of CHL: 1) CHL with xanthogranulomatous inflammation, foamy histiocytes and loose granulation tissue-like stroma; 2) epithelioid cell-rich and granulomatous CHL; 3) CHL with prominent keloid-like fibrosis; 4) CHL rich in plump histiocytes arranging in a fascicular pattern; 5) intrasinusoidal CHL; 6) interfollicular CHL: 7) neutrophil-rich CHL; 8) neoplastic cell-rich CHL; 9) lymphocyte depleted CHL; 10) CHL with aberrant immunophenotypes; 11) grey-zone CHL. These variants pose diagnostic pitfalls to the practicing pathologists.

Keywords

Classic Hodgkin lymphoma, anaplastic large cell lymphoma, immunohistochemistry

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Fratoni, S. & Niscola, P., (2019) “The Uncommon Faces of Classic Hodgkin Lymphoma”, Hematopathology 4(1), p.9-23.

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Authors

Stefano Fratoni (St. Eugenio Hospital of Rome, Italy)
Pasquale Niscola (Saint’ Eugenio Hospital, Rome, Italy)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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