B-Lymphoblastic Leukemia/Lymphoma with CRLF2 Overexpression: A Case Study of Three Patients

Abstract

B-lymphoblastic leukemia/lymphoma with CRLF2 overexpression belongs to the BCR-ABL1-like B- lymphoblastic leukemia / lymphoma group (BCR-ABL1-like B-ALL), also known as Philadelphia chromosome-like B-ALL, a recently recognized provisional entity in the latest edition of World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues (2016). Although lacking the classic t(9;22) BCR-ABL1, BCR-ABL1-like B-ALL shares a similar gene expression profile with BCR-ABL1 translocation associated B-ALL. BCR-ABL1-like B-ALL often have translocations involving CRLF2, EPOR, or other tyrosine kinases. Due to prognostic importance and potential therapeutic differences, it is important to recognize and diagnose BCR-ABL1-like B-ALL in a timely manner. In this report, we describe a series of three adult patients with the diagnosis of B-ALL with CRLF2 overexpression and present all relevant clinical and pathologic findings.

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Williams, M. & Li, K. D., (2018) “B-Lymphoblastic Leukemia/Lymphoma with CRLF2 Overexpression: A Case Study of Three Patients”, Hematopathology 3(1), p.7-13.

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Authors

Margaret Williams (University of Utah and ARUP Laboratories, Salt Lake City)
K. David Li (University of Utah and ARUP Laboratories, Salt Lake City)

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Creative Commons Attribution-NonCommercial 4.0

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