Monosomy 7 or partial loss in the long arm of this chromosome is a recurrent nonrandom cytogenetic finding associated with a variety of hematological disorders. In the present case, a 9-month-old male presented with a febrile illness along with anemia and thrombocytopenia, and achieved spontaneous remission of the bicytopenia and monosomy 7 without any intervention 28 months after initial diagnosis. To our knowledge and literature search, this is likely the first case report of transient monosomy 7 in a patient with only bicytopenia. It is critical to closely monitor patients with monosomy 7 for evidence of spontaneous remission before proceeding to any major treatment.
monosomy 7, bicytopenia, spontaneous remission, fluorescence in situ hybridization, karyotype
How to Cite
Yang, G. & Rowsey, R. A. & Wang, J. & Ketterling, R. P. & Fisher, R., (2017) “Transient monosomy 7 associated with bicytopenia in a 9-month-old boy: Report of a case and review of the literature”, Hematopathology 2(1), p.24-30.