ALK-positive Anaplastic Large Cell Lymphoma presenting as a solitary bladder neoplasm: A case report and review of the literature

Abstract

Anaplastic large-cell lymphoma (ALCL) with involvement of the urinary bladder is rare. We report a unique case of ALK-positive ALCL in a 17-year-old male patient. He presented with dysuria for three months and gross hematuria for one month. The computed tomography scan and the cystoscopy revealed a single broad-based lesion measuring 3x2 cm on the right lateral wall of the urinary bladder. There was no lymphadenopathy and no tumor outside of the bladder. Biopsy of the lesion showed diffuse large pleomorphic cells infiltrating the lamina propria and strongly expressing CD30, ALK, and T-cell markers. A clonal TCR-gamma gene rearrangement was detected by PCR and ALK gene rearrangement was observed by fluorescence in situ hybridization. The patient was not treated and remains asymptomatic 6 months after the diagnosis. This is the eleventh documented instance of ALCL involving the bladder and the second reported cases of localized primary bladder ALK-positive ALCL.

Keywords

Anaplastic large-cell lymphoma, Anaplastic lymphoma kinase, Bladder

How to Cite

Huang, Y. & Yuan, J. & He, H. & Li, X. & Yu, Q. & Li, G. & Li, D., (2016) “ALK-positive Anaplastic Large Cell Lymphoma presenting as a solitary bladder neoplasm: A case report and review of the literature”, Hematopathology 1(2), p.102-107.

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Authors

Ying Huang (Chongqing Medical University)
Ji Yuan (University of Nebraska Medical Center)
Hong He (First Affiliated Hospital)
Xiaomei Li (Chongqing Medical University)
Qiubo Yu (Chongqing Medical University)
Gang Li (Chongqing Medical University)
Dan Li (Chongqing Medical University)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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