Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma most commonly observed in the oral mucosae of HIV-positive patients, with increasing recognition of cases occurring in HIV-negative individuals. There is a noted association between PBL and Epstein-Barr virus (EBV), and chromosomal rearrangements involving c-MYC have been implicated in oncogenesis. There have been eight previously described cases of PBL involving the stomach in HIV-negative patients. This report details the first known case of EBV- positive gastric PBL, which was identified in an 82-year-old HIV-negative man. The patient was treated with CHOP-based chemotherapy followed by radiation, and expired eleven months after the initial diagnosis. PBL may be an under recognized entity when it presents in HIV-negative individuals, and should be considered in the differential diagnosis of high-grade lymphomas with plasmacytic or plasmablastic differentiation. Further studies are required to elucidate the pathogenesis of this neoplasm and define optimal treatment strategies.
Plasmablastic lymphoma, PBL, Epstein-Barr virus, EBV, gastrointestinal lymphoma
How to Cite
Amenta, E. M. & Allakhverdieva, E. A. & Huston, J. C. & Haycocks, N. G., (2016) “EBV-positive gastric plasmablastic lymphoma in an HIV-negative adult”, Hematopathology 1(2), 90-95.