EBV-positive gastric plasmablastic lymphoma in an HIV-negative adult

Abstract

Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma most commonly observed in the oral mucosae of HIV-positive patients, with increasing recognition of cases occurring in HIV-negative individuals. There is a noted association between PBL and Epstein-Barr virus (EBV), and chromosomal rearrangements involving c-MYC have been implicated in oncogenesis. There have been eight previously described cases of PBL involving the stomach in HIV-negative patients. This report details the first known case of EBV- positive gastric PBL, which was identified in an 82-year-old HIV-negative man. The patient was treated with CHOP-based chemotherapy followed by radiation, and expired eleven months after the initial diagnosis. PBL may be an under recognized entity when it presents in HIV-negative individuals, and should be considered in the differential diagnosis of high-grade lymphomas with plasmacytic or plasmablastic differentiation. Further studies are required to elucidate the pathogenesis of this neoplasm and define optimal treatment strategies.

Keywords

Plasmablastic lymphoma, PBL, Epstein-Barr virus, EBV, gastrointestinal lymphoma

How to Cite

Amenta, E. M. & Allakhverdieva, E. A. & Huston, J. C. & Haycocks, N. G., (2016) “EBV-positive gastric plasmablastic lymphoma in an HIV-negative adult”, Hematopathology 1(2), p.90-95.

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Eva M. Amenta (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)
Elvira A. Allakhverdieva (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)
John C. Huston (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)
Neil G. Haycocks (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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