Myelodysplastic syndrome following precursor B-cell acute lymphoblastic leukemia with low hypodiploid / near triploid karyotype and concomitant TP53 mutation: A case report and review of the literature

Abstract

Low hypodiploid / near triploid acute lymphoblastic leukemia (LH-ALL) is infrequent in children with precursor B-cell acute lymphoblastic leukemia, and development of a secondary malignancy, particularly myelodysplastic syndrome (MDS), is additionally uncommon. Here we report a case of a 12-year-old girl who initially presented with a precursor B-cell acute lymphoblastic leukemia characterized by a karyotype with a chromosome count of 34 accompanied by a near triploid clone with 63 chromosomes. These findings prompted a TP53 mutation study, which found a deleterious mutation (524G!A) resulting in an amino acid substitution of R175H (Arg175!His). Two years after successful treatment of the LH-ALL a bone marrow examination demonstrated dyserythropoiesis, dysmegakaryopoiesis, increased hematogones, and a 7q deletion consistent with MDS. The development of MDS following treatment of LH-ALL is exceptionally rare, with only one other case found in our search of available literature.

Keywords

Myelodysplasia, acute lymphoblastic leukemia, low hypodiploid / near triploid karyotype, TP53 mutation

How to Cite

Chintalapati, S. & Dietz, R. L. & Kheradpour, A. & Wang, J., (2016) “Myelodysplastic syndrome following precursor B-cell acute lymphoblastic leukemia with low hypodiploid / near triploid karyotype and concomitant TP53 mutation: A case report and review of the literature”, Hematopathology 1(1), p.69-73.

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Authors

Suneetha Chintalapati (Loma Linda University Medical Center)
Robin L. Dietz (Loma Linda University Medical Center)
Alberto Kheradpour (Loma Linda University Children’s Hospital)
Jun Wang (Loma Linda University Medical Center)

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Creative Commons Attribution-NonCommercial 4.0

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