Follicular lymphoma (FL) is the most common well defined malignant lymphoma in the adults. Besides the classical pattern of effaced nodal architecture by back-to-back lymphoid follicles/nodules, it shows many morphological variations. Using actual cases, this article will illustrate the morphological features of these FL variants. In part 1, I will present 6 FL variants: 1) In situ FL and "early" interfollicular/partial nodal involvement by FL; 2) FL, floral variant ("cloudy variant"); 3) FL with abundant eosinophilic precipitate; 4) FL with marginal zone differentiation; 5) FL with plasmacytic differentiation; and 6) Pediatric FL. Pathologists should be familiar with these morphological variations to avoid mistakes in diagnosing FLs.
Follicular lymphoma, morphologic variants
How to Cite
Fratoni, S., (2016) “The many rare faces of follicular lymphoma – Part 1”, Hematopathology 1(1), p.34-47.