Central nervous system relapsed B-Lymphoblastic Leukemia with t(9;22)(q34;q11) BCR/ABL1 mimicking acute myeloid leukemia

Abstract

The presence of the Philadelphia (Ph) chromosome is one of the worst prognostic factors in B-cell acute lymphoblastic leukemia (B-ALL). Cerebrospinal fluid (CSF) involvement is a high-risk factor and serious complication in patients with B-ALL. Here we report a 21-year-old female diagnosed with Ph positive B-ALL and subsequently developed CSF relapse and rapid demise. Her CSF contained numerous blasts resembling myeloblasts. The relevant clinicopathologic distinctive scenarios and differential diagnoses are discussed.

Keywords

B-lymphoblastic leukemia (B-ALL), Blasts, Cerebrospinal Fluid, Philadelphia chromosome

How to Cite

Su, R. J. & Huang, E. C. & Chen, M., (2016) “Central nervous system relapsed B-Lymphoblastic Leukemia with t(9;22)(q34;q11) BCR/ABL1 mimicking acute myeloid leukemia”, Hematopathology 1(2), p.108-113.

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Authors

Ruijun J. Su (University of California Davis Medical Center)
Eric C. Huang (University of California Davis Medical Center)
Mingyi Chen (University of California Davis Medical Center)

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Creative Commons Attribution-NonCommercial 4.0

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This article has been peer reviewed.

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