The presence of the Philadelphia (Ph) chromosome is one of the worst prognostic factors in B-cell acute lymphoblastic leukemia (B-ALL). Cerebrospinal fluid (CSF) involvement is a high-risk factor and serious complication in patients with B-ALL. Here we report a 21-year-old female diagnosed with Ph positive B-ALL and subsequently developed CSF relapse and rapid demise. Her CSF contained numerous blasts resembling myeloblasts. The relevant clinicopathologic distinctive scenarios and differential diagnoses are discussed.
B-lymphoblastic leukemia (B-ALL), Blasts, Cerebrospinal Fluid, Philadelphia chromosome
How to Cite
Su, R. J. & Huang, E. C. & Chen, M., (2016) “Central nervous system relapsed B-Lymphoblastic Leukemia with t(9;22)(q34;q11) BCR/ABL1 mimicking acute myeloid leukemia”, Hematopathology 1(2), p.108-113.